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Different clinical tests were done to prove
the effectiveness with which Serilesine helps
to keep skin aging at bay by stimulating various mechanisms.
This page looks at how it helps to stimulate the production of laminin-5.
To place this in context with how it helps to fight aging and to have a younger looking skin, please look at the Serilesine summary page by clicking here.
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Serilesine is used in the following products: |
The full thickness skin models exhibit in vivo-like morphological, metabolical, and growth characteristics which are uniform and highly reproducible.
These skin-like tissues consists of organized basal, spinous, granular and cornified epidermal layers analogous to those found in vivo (1).
Human skin tissue models were used to monitor the levels of Laminin-5.
EpidermFT full thickness skin model (supplied by Mattek Corporation, Ashland, MA, USA) consists of normal, human-derived epidermal keratinocytes (NHEK) and normal, human-derived dermal fibroblasts (NHFB), which have been cultured to form a multilayered, highly differentiated model of the human dermis and epidermis.
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| Control sample - untreated |
Sample treated with Serilesine 0.005% |
Fluorescent quantification by image analysis demonstrate that Laminin-5 is expressed 20% more in treated tissues than in controls, and this helps to fight aging by assisting with a younger looking skin.
Due to the fact that combining all the images on one page makes it too large to download within a fair period of time, we created different pages dealing with each aspect that was tested.
The other test that were performed can be viewed by clicking the hyperlink.
If you are looking for the summary page of Serilesine please click here.
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